Dopamine dynamics in chronic pain: music-induced, sex-dependent, behavioral effects in mice.

ABSTRACT:

Introduction

Chronic pain is a debilitating disease that is usually comorbid to anxiety and depression. Current treatment approaches mainly rely on analgesics but often neglect emotional aspects. Nonpharmacological interventions, such as listening to music, have been incorporated into clinics to provide a more comprehensive management of chronic pain. However, the underlying mechanisms of music-mediated pain relief are not fully understood.

Objectives

Our aim was to evaluate the effects and mechanisms of music exposure in an animal model of chronic pain.

Methods

We injected mice with the complete Freund adjuvant (CFA) inflammatory agent into the hind paw and housed them for 14 days with background music, or ambient noise, during their active period (Mozart K.205, over

SUBMITTER: Flores-Garcia M 

PROVIDER: S-EPMC11631031 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature