Identifying the molecular mechanism of blood stasis syndrome through the symptom phenotype-genotype association approach.

ABSTRACT: In traditional medicine (TM), blood stasis syndrome (BSS) is characterized by insufficient blood flow, resulting in a group of symptoms such as fixed pain, a dark complexion, bleeding, and an astringent pulse. While BSS pathology has been previously explored, its molecular mechanisms remain elusive owing to challenges in linking TM symptoms to genes. Our study aimed to elucidate the mechanisms underlying BSS using a phenotype-genotype association approach. We extracted BSS symptoms from various studies, linked them to medical terms using a Unified Medical Language System, and connected these terms to genes in the DisGeNET database. The molecular network patterns of BSS symptoms were revealed through analyzing protein-protein interactions and symptom-gene associations. Our findings revealed

SUBMITTER: Tran MN 

PROVIDER: S-EPMC11631032 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature