The Hippo Coactivator TAZ Exacerbates Cisplatin-Induced Acute Renal Injury.

ABSTRACT:

Introduction

Transcriptional coactivator with PDZ-binding motif (TAZ), a Hippo signaling pathway effector, maintains the balance of cell proliferation, differentiation, and death. However, the role of TAZ in tubular cell survival and acute kidney injury (AKI) remains largely unknown.

Methods

We used the RNA-seq database, Western blot, and immunohistochemistry to examine TAZ expression in kidneys from cisplatin-induced AKI. We generated tubular-specific TAZ knockout mice to assess the role of TAZ in cisplatin-induced renal toxicity. Immunoprecipitation-mass spectrometry followed standard procedures.

Results

TAZ was activated in tubular cells in kidneys injected with cisplatin. Conditional deletion of TAZ in tubular cells confers ferroptosis resistance and protects kidn

SUBMITTER: Xue X 

PROVIDER: S-EPMC11631110 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature