Predictive Value of Serum Hepcidin Levels for the Risk of Incident End-Stage Kidney Disease in Patients with Chronic Kidney Disease: The KNOW-CKD.

ABSTRACT:

Introduction

Despite the pivotal role of hepcidin in the development of anemia among the patients with chronic kidney disease (CKD), the association between serum hepcidin levels and CKD progression has been never investigated. We here hypothesized that elevation in serum hepcidin levels might be associated with the risk of incident end-stage kidney disease (ESKD) among the patients with pre-dialysis CKD.

Methods

A total of 2,109 patients with pre-dialysis CKD at stages 1 to pre-dialysis 5 were categorized into the quartiles by serum hepcidin levels. The study outcome was incident ESKD. The median duration of follow-up was 7.9 years.

Results

The analysis of the baseline characteristics revealed that unfavorable clinical features were in general associated with higher

SUBMITTER: Suh SH 

PROVIDER: S-EPMC11631166 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature