Multiple-Wave Admixture and Adaptive Evolution of the Pamirian Wakhi People.

ABSTRACT: While whole-genome sequencing has been applied extensively to investigate the genetic diversity of global populations, ethnic minority groups in Pakistan are generally underrepresented. In particular, little is known about the genetic origin and highland adaptation of the Pamirian Wakhi people. According to Chinese historical records, the geographical location and language usage of Wakhi may be closely related to Xinjiang Tajiks. In this study, based on high-coverage (∼30×) whole-genome sequencing of eight Wakhi and 25 Xinjiang Tajik individuals, we performed data analyses together with worldwide populations to gain insights into their genetic composition, demography, and adaptive evolution to the highland environment. The Wakhi derived more than 85% of their ancestry from West Eurasian po

SUBMITTER: Xu W 

PROVIDER: S-EPMC11631187 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature