Natural history and clinical outcomes of patients with hypertrophic cardiomyopathy from thin filament mutations.

ABSTRACT: Hypertrophic cardiomyopathy (HCM) due to thick filament variants is more common; however, HCM due to thin filament variants (HCM-Thin) may be associated with a more malignant phenotype with an increased risk of sudden cardiac death. The aim of this study was to review all the published cases of HCM-Thin to better understand the natural history and clinical outcomes of this disease. A literature review of HCM-Thin identified 21 studies with a total of 177 patients that were suitable for analysis. There were three outcomes of interest, which included a heart failure composite, a ventricular arrhythmia composite and a heart failure and arrhythmia composite outcome. Kaplan-Meier (KM) survival analyses for freedom from each of the abovementioned composite outcomes were completed for the entire

SUBMITTER: Saul T 

PROVIDER: S-EPMC11631233 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature