Genotype is associated with left ventricular reverse remodelling and early events in recent-onset dilated cardiomyopathy.

ABSTRACT:

Aims

Recent-onset dilated cardiomyopathy (RODCM) is characterized by heterogeneous aetiology and diverse clinical outcomes, with scarce data on genotype-phenotype correlates. Our aim was to correlate individual RODCM genotypes with left ventricular reverse remodelling (LVRR) and clinical outcomes.

Methods and results

In this prospective study, a total of 386 Czech RODCM patients with symptom duration ≤6 months underwent genetic counselling and whole-exome sequencing (WES). The presence of pathogenic (class 5) or likely pathogenic (class 4) variants in a set of 72 cardiomyopathy-related genes was correlated with the occurrence of all-cause death, heart transplantation, or implantation of a ventricular assist device (primary outcome) and/or ventricular arrhythmia event (second

SUBMITTER: Kubanek M 

PROVIDER: S-EPMC11631235 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature