Phenotype and prognostic factors in geriatric and non-geriatric patients with transthyretin cardiomyopathy.

ABSTRACT:

Aims

Transthyretin cardiac amyloidosis (ATTR-CM) may be an underestimated cause of heart failure among geriatric patients and represent a unique phenotype and prognostic profile.

Methods and results

This retrospective, observational, cohort study characterizes cardiac and extracardiac disorders at diagnosis and assesses prognosis among ATTR-CM patients based on age (geriatric vs. non-geriatric) and amyloidosis subtype (wild type, ATTRwt and hereditary, ATTRv). In total, 943 patients with ATTR-CM were included, of which 306 had ATTRv and 637 had ATTRwt. Among these, 331 (35.1%) were non-geriatric (<75 years), and 612 (64.9%) were geriatric (≥75 years). The population exhibited conduction abnormalities, atrial fibrillation and ischaemic heart disease that progressively deterio

SUBMITTER: Volpentesta E 

PROVIDER: S-EPMC11631254 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature