Relationships Between Markers of Iron Status and Hematological Parameters in Patients With Sickle Cell Disease.

ABSTRACT: Based on the relationship between the intracellular concentration of sickle hemoglobin S (HbS) and the delay that occurs prior to the onset of sickling following deoxygenation, targeting the intracellular HbS concentration is a recognized therapeutic approach for sickle cell disease (SCD). We and others have shown that restricting iron by dietary or pharmacologic means improves hematologic parameters, inflammation, and organ damage in mouse models of SCD. Clinical evidence corroborating these findings is confined to case reports and small case series studies, none of which account for treatment or α-thalassemia. We hypothesize that increased transferrin saturation is associated with increased mean cellular hemoglobin concentration (MCHC) which in turn is associated with decreased re

SUBMITTER: Parrow NL 

PROVIDER: S-EPMC11631288 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature