TLR and IKK Complex-Mediated Innate Immune Signaling Inhibits Stress Granule Assembly.

ABSTRACT: Cellular stress can induce cytoplasmic ribonucleoprotein complexes called stress granules that allow the cells to survive. Stress granules are also central to cellular responses to infections, in which they can act as platforms for viral sensing or modulate innate immune signaling through pattern recognition receptors. However, the effect of innate immune signaling on stress granules is poorly understood. In this study, we report that prior induction of innate immune signaling through TLRs inhibited stress granule assembly in a TLR ligand dose-dependent manner in murine bone marrow-derived macrophages. Time course analysis suggests that TLR stimulation can reverse stress granule assembly even after it has begun. Additionally, both MYD88- and TRIF-mediated TLR signaling inhibited stress gra

SUBMITTER: Samir P 

PROVIDER: S-EPMC11631289 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature