Predictive value of NT pro BNP for new-onset atrial fibrillation in heart failure and preserved ejection fraction.

ABSTRACT:

Aims

The prognostic significance of N-terminal pro B-type natriuretic peptide (NT-proBNP) in heart failure with preserved ejection fraction (HFpEF) has been well established. HFpEF and atrial fibrillation (AF) commonly coexist, and each contributes to poor outcomes independently. Nevertheless, the ability of NT-proBNP to predict AF in HFpEF patients remains uncertain.

Methods and results

A total of 367 HFpEF patients without baseline AF from the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial were included. The Cox proportional hazard model was used to assess the association of NT-proBNP with the risk of AF. The C-statistic, categorical net reclassification index (NRI), and integrated discrimination improvement (IDI) were u

SUBMITTER: Liu X 

PROVIDER: S-EPMC11631295 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature