Pro-adrenomedullin associates with congestion in acute heart failure patients.

ABSTRACT:

Aim

Congestion is a major determinant of outcomes in acute heart failure. Its assessment is complex, making sufficient decongestive therapy a challenge. Residual congestion is frequent at discharge, increasing the risk of re-hospitalization and death. Mid-regional pro-adrenomedullin mirrors vascular integrity and may therefore be an objective marker to quantify congestion and to guide decongestive therapies in patients with acute heart failure.

Methods and results

Observational, prospective, single-centre study in unselected patients presenting with acute heart failure. This study aimed to assess adrenomedullin's association with congestion and clinical outcomes: in-hospital death, post-discharge mortality and in-hospital worsening heart failure according to RELAX-AHF-2 tria

SUBMITTER: Beer BN 

PROVIDER: S-EPMC11631323 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature