Alterations in Gut Microbiota Correlate With Hematological Injuries Induced by Radiation in Beagles.

ABSTRACT: Dynamics of gut microbiota and their associations with the corresponding hematological injuries postradiation remain to be elucidated. Using single whole-body exposure to ⁶⁰Co-γ ray radiation at the sublethal dose of 2.5 Gy, we developed a beagle model of acute radiation syndrome (ARS) and then monitored the longitudinal changes of gut microbiome and hematology for 45 days. We found that the absolute counts of circulating lymphocytes, neutrophils, and platelets were sharply declined postradiation, accompanied by a largely shifted composition of gut microbiome that manifested as a significantly increased ratio of Firmicutes to Bacteroidetes. In irradiated beagles, alterations in hematological parameters reached a nadir on day 14, sustaining for 1 week, which

SUBMITTER: Huang Z 

PROVIDER: S-EPMC11631345 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature