Interference Mechanisms of Endocrine System and Other Systems of Endocrine-Disrupting Chemicals in Cosmetics-In Vitro Studies.

ABSTRACT: Endocrine-disrupting chemicals (EDCs), found in various cosmetic products, interfere with the normal functioning of the endocrine system, impacting hormone regulation and posing risks to human health. Common cosmetic EDCs, such as ultraviolet (UV) filters, parabens, and triclosan, can enter the human body through different routes, including skin absorption. Their presence has been linked to adverse effects on reproduction, immune function, and development. High-throughput in vitro assays, using various human cell lines, were employed to assess the effects of common cosmetic EDCs such as ethylhexyl methoxycinnamate (EHMC), benzophenone-3 (BP-3), homosalate, and parabens. Despite ongoing regulatory efforts, gaps persist in understanding their long-term impacts, particularly when they are pre

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11631346 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature