IL-17 is associated with disease severity and targetable inflammatory processes in heart failure.

ABSTRACT:

Aims

Heart failure (HF) is recognized as an inflammatory disease in which cytokines play an important role. In animal HF models, interleukin-17A (IL-17) has been linked to deterioration of cardiac function and fibrosis, whereas knock-out of IL-17 showed beneficial cardiac effects. However, there is limited evidence of IL-17 involvement in patients with HF. This study aims to investigate the clinical characteristics, outcomes, and pathophysiological processes associated with circulating IL-17 concentrations in patients with HF.

Methods and results

IL-17 was measured by ELISA in 2082 patients diagnosed with HF along with 363 circulating proteins using proximity extension assay technology for differential expression and pathway analysis. Data were validated in an independent co

SUBMITTER: Baumhove L 

PROVIDER: S-EPMC11631355 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature