Saturation transfer (CEST and MT) MRI for characterization of U-87 MG glioma in the rat.

ABSTRACT: The focus of this work was to identify the optimal magnetic resonance imaging (MRI) contrast between orthotopic U-87 MG tumours and normal appearing brain with the eventual goal of treatment response monitoring. U-87 MG human glioblastoma cells were injected into the brain of RNU nude rats (n = 9). The rats were imaged at 7 T at three timepoints for all animals: 3-5, 7-9, and 11-13 days after implantation. Whole-brain T₁-weighted (before and after gadolinium contrast agent injection), diffusion, and fluid-attenuated inversion recovery scans were performed. In addition, single-slice saturation-transfer-weighted chemical exchange saturation transfer (CEST), magnetization transfer (MT), and water saturation shift referencing (WASSR) contrast Z-spectra and T₁ and T_2<

SUBMITTER: Lam WW 

PROVIDER: S-EPMC11631369 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature