Mutation potentiates migration swamping in polygenic local adaptation.

ABSTRACT: Locally adapted traits can exhibit a wide range of genetic architectures, from pronounced divergence at a few loci to small frequency divergence at many loci. The type of architecture that evolves depends strongly on the migration rate, as weakly selected loci experience swamping and do not make lasting contributions to divergence. Simulations from previous studies showed that even when mutations are strongly selected and should resist migration swamping, the architecture of adaptation can collapse and become transient at high mutation rates. Here, we use an analytical two-population model to study how this transition in genetic architecture depends upon population size, strength of selection, and parameters describing the mutation process. To do this, we develop a mathematical theory base

SUBMITTER: Sakamoto T 

PROVIDER: S-EPMC11631501 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature