Population pharmacokinetics and dose optimization of ceftazidime in critically ill children.

ABSTRACT:

Objective

The aim of this study was to develop a population pharmacokinetic model for ceftazidime in critically ill children in the pediatric intensive care unit (PICU) and optimize an appropriate dosing regimen for this population.

Methods

We performed a prospective pharmacokinetic study on critically ill children aged 0.03-15 years. A population pharmacokinetic model was developed using the NLME program. Statistical and graphical methods were used to assess the stability and predictive performance of the model. Monte Carlo simulations were conducted to determine the optimal ceftazidime dosing regimen to achieve 70% fT > minimum inhibitory concentration (MIC).

Results

This study included 88 critically ill children and 100 ceftazidime serum concentrations. The

SUBMITTER: Li M 

PROVIDER: S-EPMC11631598 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature