Evaluation of the effect of hemodynamic factors on retinal microcirculation by using 3D confocal image-based computational fluid dynamics.

ABSTRACT:

Purpose

To investigate local hemodynamic changes resulting from elevated intraocular pressure (IOP) in different vasculature networks using a computational fluid dynamics model based on 3D reconstructed confocal microscopic images.

Methods

Three-dimensional rat retinal vasculature was reconstructed from confocal microscopy images using a 3D U-Net-based labeling technique, followed by manual correction. We conducted a computational fluid dynamics (CFD) analysis on different retinal vasculature networks derived from a single rat. Various venule and arteriole pressures were applied to mimic the effects of elevated intraocular pressure (IOP), a major glaucoma risk factor. An increase in IOP typically correlates with a decrease in venous pressure. We also varied the percentage of

SUBMITTER: Ong CW 

PROVIDER: S-EPMC11631608 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature