Plasma Estrogen Levels and Aneurysmal Subarachnoid Hemorrhage in Women.

ABSTRACT:

Objective

Aneurysmal subarachnoid hemorrhage (aSAH) is more prevalent in postmenopausal women, and it has been postulated that this relationship is hormonally driven by lower circulating levels of estrogens. We examined the association between circulating plasma estrogen levels and subsequent development of aSAH in women.

Methods

Women from the Nurses' Health Study with confirmed aSAH (n = 38) were matched with controls (n = 38) on age, smoking, menopausal status, and other reproductive factors. Plasma estriol, estradiol, and sex hormone-binding globulin were measured at baseline, prior to the development of aSAH. Conditional logistic regressions were performed to assess the association between hormone levels and incident aSAH.

Results

Plasma estradiol, estriol, and s

SUBMITTER: Lai PMR 

PROVIDER: S-EPMC11631632 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature