IRS2 Signaling Protects Against Stress-Induced Arrhythmia by Maintaining Ca²⁺ Homeostasis.

ABSTRACT:

Background

The docking protein IRS2 (insulin receptor substrate protein-2) is an important mediator of insulin signaling and may also regulate other signaling pathways. Murine hearts with cardiomyocyte-restricted deletion of Irs2 (cIRS2-KO) are more susceptible to pressure overload-induced cardiac dysfunction, implying a critical protective role of IRS2 in cardiac adaptation to stress through mechanisms that are not fully understood. There is limited evidence regarding the function of IRS2 beyond metabolic homeostasis regulation, particularly in the context of cardiac disease.

Methods

A retrospective analysis of an electronic medical record database was conducted to identify patients with IRS2 variants and assess their risk of cardiac arrhythmias. Arrhythmia su

SUBMITTER: Shi Q 

PROVIDER: S-EPMC11631690 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature