The circadian clock gene BMAL1 modulates autoimmunity features in lupus.

ABSTRACT:

Objectives

An important pathogenic role for neutrophils in systemic lupus erythematosus (SLE) has been proposed. Neutrophils that lack brain and muscle aryl hydrocarbon receptor nuclear translocator-like 1 (Bmal1), one of the clock genes, are defective in aging and proinflammatory responses. We assessed the role of Bmal1 in clinical and immunologic manifestations of murine lupus and in human SLE neutrophils.

Methods

Myeloid-conditional Bmal1 knockout mice (Bmal1^Mye-/- ) and wild type (WT) were treated with epicutaneous TLR7/8 agonist (imiquimod; IMQ) for 6 weeks to induce a lupus phenotype. Upon euthanasia, immune responses, autoantibodies and renal manifestations were evaluated. NET formation and gene expression of bone marrow (BM)-der

SUBMITTER: Nakabo S 

PROVIDER: S-EPMC11631884 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature