Ecology meets reproductive medicine in HIV prevention: the case for geography-informed approaches for bacterial vaginosis in Africa.

ABSTRACT:

Purpose of review

Women in Africa bear the burden of the HIV epidemic, which has been associated with the high prevalence of bacterial vaginosis (BV) in the region. However, little progress has been made in finding an effective cure for BV. Drawing on advances in microbiome-directed therapies for gastrointestinal disorders, similar live-biotherapeutic based approaches for BV treatment are being evaluated. Here, we summarize current knowledge regarding vaginal microbiota in BV, explore geographical differences in vaginal microbiota, and argue that novel BV therapeutics should be tailored specifically to meet the needs of African women.

Recent findings

Cervicovaginal microbiota dominated by Lactobacillus crispatus are optimal, although these are uncommon in African wome

SUBMITTER: Passmore JS 

PROVIDER: S-EPMC11631894 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature