Unveiling the role of TGF-β signaling pathway in breast cancer prognosis and immunotherapy.

ABSTRACT:

Introduction

The TGF-β signaling pathway (TSP) is pivotal in tumor progression. Nonetheless, the connection between genes associated with the TSP and the clinical outcomes of breast cancer, as well as their impact on the tumor microenvironment and immunotherapeutic responses, remains elusive.

Methods

Breast cancer transcriptomic and single-cell sequencing data were obtained from the The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. We identified 54 genes associated with the TSP from the Molecular Signatures Database (MSigDB) and analyzed both data types to evaluate TSP activity. Using weighted gene co-expression network analysis (WGCNA), we identified modules linked to TSP activity. To assess patient risk, we used 101 machine learning algorithms

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC11631921 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature