Low serum Metrnl levels are associated with increased risk of sarcopenia in the older adults.

ABSTRACT:

Purpose

Sarcopenia is a geriatric syndrome characterized by progressive loss of muscle mass and function. Meteorin-like (Metrnl) is a secretory protein that has protective effects on skeletal muscle injury. However, the association of Metrnl level with sarcopenia remains unclear.

Methods

A total of 772 community-dwelling older adults (median age = 76 years), comprising 409 males and 363 females, from both urban and rural areas were enrolled. Serum Metrnl was measured by enzyme-linked immunosorbent assay. Appendicular skeletal muscle mass index (ASMI), grip strength, and gait speed were measured for the assessment of sarcopenia.

Results

We found that serum Metrnl levels were lower in patients with sarcopenia [median (IQR) = 180.1 (151.3-220.3) pg/mL] than older adults

SUBMITTER: Wang ZY 

PROVIDER: S-EPMC11632026 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature