Environmental and inflammatory factors influencing concurrent gut and lung inflammation.

ABSTRACT:

Background

Crohn's disease and chronic obstructive pulmonary disease (COPD) are chronic inflammatory diseases that affect the gut and lung respectively and can occur comorbidly.

Methods

Using the SHIP-1^-/- model of Crohn's-like ileitis and chronic lung inflammation, the two diseases were co-investigated.

Results

Contrary to prior literature, Crohn's-like ileitis was not fully penetrant in SHIP-1^-/- mice, and housing in a specific pathogen-free facility was completely protective. Indeed, ileal tissue from SHIP-1^-/- mice without overt ileitis was similar to control ilea. However, SHIP-1^-/- mice with ileitis exhibited increased granulocytes in ileal tissue together with T cell lymphopenia and they lacked low abundance Bifidobac

SUBMITTER: Raftery AL 

PROVIDER: S-EPMC11632041 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature