Enpp1 mutations promote upregulation of hedgehog signaling in heterotopic ossification with aging.

ABSTRACT:

Introduction

Heterotopic ossification of the tendon and ligament (HOTL) is a chronic progressive disease that is usually accompanied by thickening and ossification of ligaments and high osteogenic activity of the surrounding ligament tissue. However, the molecular mechanism of maintaining the cellular phenotype of HOTL remains unclear.

Materials and methods

We first constructed a model of HOTL, Enpp1^flox/flox/EIIa-Cre mice, a novel genetic mouse system. Imaging, histological, and cell-level analyses were performed to investigate the progressive ossification of the posterior longitudinal ligament, Achilles tendons, and degeneration joints caused by Enpp1 deficiency.

Results

The results indicate that Enpp1 deficiency led to markedly progressive heterotopic os

SUBMITTER: He Z 

PROVIDER: S-EPMC11632054 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature