Detoxification of hydrogen sulfide by synthetic heme model compounds.

ABSTRACT: Hydrogen sulfide is a lethal toxic gas that disrupts cellular respiration in the mitochondrial system. Currently, no antidote is available for the clinical treatment of hydrogen sulfide poisoning. In this study, we investigated the function of iron(III)porphyrin complexes as hydrogen sulfide scavengers in water and evaluated their potential use as therapeutic agents for hydrogen sulfide poisoning. The compounds, named met-hemoCD-P and met-hemoCD-I, are composed of iron(III)porphyrin complexed with per-methylated β-cyclodextrin dimers that contain a pyridine (met-hemoCD-P) or imidazole axial fifth ligand that is coordinated to Fe(III) (met-hemoCD-I). These compounds formed stable HS-Fe(III) complexes under physiological conditions, with binding constants of 1.2 × 10⁵ and 2.5 × 10

SUBMITTER: Nakagami A 

PROVIDER: S-EPMC11632086 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature