Role of eosinophil counts in mediating the association between asthma and colon cancer.

ABSTRACT:

Background

Epidemiological findings regarding the association between asthma and the risk of colon cancer (CC) are inconsistent. The causality and potential molecular mechanisms underlying asthma, eosinophil count, and CC remain unknown.

Methods

We performed Mendelian randomization (MR) analysis to investigate the causality between asthma and CC and attempted to demonstrate that asthma indirectly affects CC mediated by eosinophil count through mediation analysis. Sensitivity analyses and multivariable MR were performed to test the robustness of our findings. Multiple bioinformatics tools were applied to further investigate the underlying mechanisms related to eosinophils that contribute to the pathogenesis of both asthma and CC.

Results

MR with mediation analyses sugg

SUBMITTER: Zhan ZQ 

PROVIDER: S-EPMC11632118 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature