Gut microbiota dysbiosis in patients with Alzheimer's disease and correlation with multiple cognitive domains.

ABSTRACT:

Background

Accumulating evidence suggested that Alzheimer's disease (AD) was associated with altered gut microbiota. However, the relationships between gut microbiota and specific cognitive domains of AD patients have yet been fully elucidated. The aim of this study was to explore microbial signatures associated with global cognition and specific cognitive domains in AD patients and to determine their predictive value as biomarkers.

Methods

A total of 64 subjects (18 mild AD, 23 severe AD and 23 healthy control) were recruited in the study. 16 s rDNA sequencing was performed for the gut bacteria composition, followed by liquid chromatography electrospray ionization tandem mass spectrometry (LC/MS/MS) analysis of short-chain fatty acids (SCFAs). The global cognition, specific

SUBMITTER: Chen Q 

PROVIDER: S-EPMC11632125 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature