Dosimetric scorecards express precise clinical intent: alternate hippocampal-sparing whole-brain RapidPlan models favoring target coverage and homogeneity at 30 and 20 Gy.

ABSTRACT:

Introduction

This study develops two new multi-institutional hippocampal-sparing whole-brain RapidPlan™ models (HLS-EC-WB and HMS-EC-WB) inspired by CCTG-CE.7 featuring enhanced target coverage with varying hippocampal sparing (limited and moderate).

Methods

New dosimetric scorecards were created to quantify the models' clinical intent. The models were trained using a multi-institution dataset, and a recursive method was employed to generate consistent, high-quality plans. The models were validated using a five-case set and compared at 20- and 30-Gy prescriptions.

Results

Each model scored highest on its associated dosimetric scorecard. The new models achieved higher brain PTV prescription coverage (98%-99%) compared to the previous HSWBv2 model (95.12%), with some tr

SUBMITTER: Rayn K 

PROVIDER: S-EPMC11632126 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature