<i>Cutibacterium acnes</i> strains associated with bone prosthesis infections cannot evade the host immune system.

ABSTRACT:

Introduction

Cutibacterium acnes is a commensal skin bacterium that is involved in bone prosthesis infections (BPIs) and presents low-grade clinical symptoms. C. acnes has been thought to escape the immune system at bone sites.

Material and methods

Our study was carried out on a laboratory strain and two BPI-related clinical strains, one of which surprisingly induced clinical symptoms of inflammation in the patient. We investigated the ability of these C. acnes strains to trigger in vitro human primary neutrophils (PMN) response through inflammatory mediators measurements (antibody arrays, ELISA, RT-qPCR, zymography) and activation status assessment (flow cytometry), and to induce in vivo PMN recruitment from the bloodstream in mice air-pou

SUBMITTER: Thoraval L 

PROVIDER: S-EPMC11632127 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature