Genome mining of Bacillus thuringiensis strain SY49.1 reveals novel candidate pesticidal and bioactive compounds.

ABSTRACT:

Background

Bacillus thuringiensis SY49.1 (Bt SY49.1) strain has promising insecticidal and fungicidal activity against phytopathogens and pests. Therefore, we selected this strain for whole-genome sequencing (WGS), annotation and analysis, with the aim of identifying genes responsible for producing putative pesticidal toxins, antimicrobial metabolites and plant growth-promoting features.

Results

Our results showed that the SY49.1 genome is 6. 32 Mbp long with a GC content of 34.68%. Genome mining revealed the presence of multiple gene inventories for the biosynthesis of bioactive compounds such as insecticidal delta endotoxins, secondary metabolites, and several plant growth-promoting proteins. Multiple sequence alignment revealed residue variations in the toxic core of Cry1

SUBMITTER: Yılmaz S 

PROVIDER: S-EPMC11632210 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature