Multi-omics analysis reveals indicator features of microbe-host interactions during <i>Candida albicans</i> colonization and subsequent infection.

ABSTRACT:

Introduction

Candida albicans gastrointestinal (GI) colonization is crucial for the onset of invasive disease. This research encompassed 31 patients diagnosed with Candida spp. bloodstream infections during their admission to a university hospital in China.

Methods

We explored risk factors associated with C. albicans GI colonization and ensuing translocated infection. Animal models were established via gavage with clinical isolates of C. albicans to induce GI tract colonization and subsequent kidney translocation infection. Our analysis is focused on 16S rRNA gene sequencing, metabolomics of colon contents, and transcriptomics of colon tissues, examining the intestinal barrier, inflammatory responses, and immune cell infiltration.

Results

T

SUBMITTER: Zhang H 

PROVIDER: S-EPMC11632224 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature