Investigating the causal links between inflammatory cytokines and scoliosis through bidirectional Mendelian randomization analysis.

ABSTRACT:

Background

Scoliosis, characterized by a lateral curvature of the spine, affects millions globally. The role of inflammatory cytokines in the pathogenesis of scoliosis is increasingly acknowledged, yet their causal relationships remain poorly defined.

Aims

This study aims to explore the genetic-level causal relationships between inflammatory cytokines and scoliosis utilizing bidirectional Mendelian randomization (MR) analysis.

Materials and methods

This study leverages genetic data from public Genome-Wide Association Studies (GWAS). Bidirectional MR was employed to investigate the causal relationships between 44 inflammatory cytokines and scoliosis. The inflammatory cytokine data include 8293 Finnish individuals, while the scoliosis data consist of 165 850 participant

SUBMITTER: Mardan M 

PROVIDER: S-EPMC11632254 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature