Fasting as a precursor to high-fat diet enhances mitochondrial resilience in Drosophila melanogaster.

ABSTRACT: Changes in diet type and nutrient availability can impose significant environmental stress on organisms, potentially compromising physiological functions and reproductive success. In nature, dramatic fluctuations in dietary resources are often observed and adjustments to restore cellular homeostasis are crucial to survive this type of stress. In this study, we exposed male Drosophila melanogaster to two modulated dietary treatments: one without a fasting period before exposure to a high-fat diet and the other with a 24-h fasting period. We then investigated mitochondrial metabolism and molecular responses to these treatments. Exposure to a high-fat diet without a preceding fasting period resulted in disrupted mitochondrial respiration, notably at the level of complex I. On the other hand,

SUBMITTER: Hunter-Manseau F 

PROVIDER: S-EPMC11632299 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature