Implantable continuous-flow total artificial heart for newborns and small pediatric patients: First report of working model.

ABSTRACT:

Objective

The need for safe and reliable mechanical circulatory support (MCS) for smaller children with severe heart failure (HF) is well defined. More specifically, in pediatric patients with advanced congenital HF, there is no implantable total artificial heart (TAH) device available for small patients. Herein, we report the development of the infant continuous-flow total artificial heart (I-CFTAH), a fully implantable in infants and newborns.

Methods

After extensive engineering analysis, we performed an unprecedented effort: reducing the I-CFTAH's displacement volume to be 14% of the adult CFTAH pump while simultaneously decreasing pump diameter (6.2 cm to 2.6 cm) and axial length (9.8 cm to 4.8 cm). Facilitated by these proportional reductions, for the first time, a dura

SUBMITTER: Karimov JH 

PROVIDER: S-EPMC11632331 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature