Non-invasive assessment of IgA nephropathy severity with [¹⁸F]AlF-NOTA-FAPI-04 PET/CT imaging.

ABSTRACT:

Background

Renal biopsy plays a crucial role in diagnosing and assessing the severity of immunoglobulin A nephropathy (IgAN), despite being an invasive procedure with potential risk of failure. Our study focused on evaluating the capability of [¹⁸F]AlF-NOTA-FAPI-04 PET/CT in identifying the extent of pathological alterations in IgAN.

Methods

Twenty patients (13 males and 7 females; mean age, 44 ± 16 years) with newly diagnosed primary IgAN and 10 patients (7 males and 3 females; mean age, 51 ± 4 years) without known renal disease underwent [¹⁸F]AlF-NOTA-FAPI-04 PET/CT imaging. Kidney tissues from biopsies were stained with various techniques and examined using immunofluorescence. The Oxford classification was used to evaluate pathological indicators. Im

SUBMITTER: Wang H 

PROVIDER: S-EPMC11632375 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature