Enduring effects of psychotherapy, antidepressants and their combination for depression: a systematic review and meta-analysis.

ABSTRACT:

Introduction

Although depressive disorders are frequently associated with relapses, the sustained efficacy of therapies after their termination has been insufficiently investigated.

Objective

The aim of this study was to evaluate the current evidence of enduring effects of psychotherapy, antidepressants and their combination after the end of treatment.

Methods

PubMed and PsychINFO were systematically screened according to PRISMA guidelines (except for preregistration). Only randomized controlled trials (RCTs) between 1980 and 2022 comparing the efficacy of psychotherapy, antidepressants and their combination in adult depression at follow-up at least 12 months after termination of therapy, which could be acute phase, maintenance or relapse prevention therapy, were incl

SUBMITTER: Voderholzer U 

PROVIDER: S-EPMC11632389 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature