Recognition-Encoded Molecules: A Minimal Self-Replicator.

ABSTRACT: Nucleic acids, with their unique duplex structure, which is key for information replication, have sparked interest in self-replication's role in life's origins. Early template-based replicators, initially built on short oligonucleotides, expanded to include peptides and synthetic molecules. We explore here the potential of a class of synthetic duplex-forming oligoanilines, as self-replicators. We have recently developed oligoanilines equipped with 2-trifluoromethylphenol-phosphine oxide H-bond base pairs and we investigate whether the imine formed between aniline and aldehyde complementary monomers can self-replicate. Despite lacking a clear sigmoidal kinetic profile, control experiments with a methylated donor and a competitive inhibitor support self-replication. Further investigations wi

SUBMITTER: Rosa-Gastaldo D 

PROVIDER: S-EPMC11632402 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature