Altered carnitine transporter genes (<i>SLC22A5</i>, <i>SLC22A16</i>, <i>SLC6A14</i>) expression pattern among lung cancer patients.

ABSTRACT:

Background

Despite the decrease of morbidity rate of non-small cell lung cancer (NSCLC) in recent years, it is still a cancer with poor prognosis. Lung cancers (LCs) are usually diagnosed at a late stage of the disease due to non-specific clinical symptoms. Proper regulation of carnitine levels is important in the context of development and increased risk of cancer cells proliferation. The expression profiles and clinical value of SLC family members in LC remain largely unexplored. The aim of the study was the assessment of SLC22A16, SLC22A5 and SLC6A14 mRNA expression level among patients suffering from NSCLC. The obtained results were compared with the clinical and the pathological features of NSCLC patients.

Methods

Through reverse transcriptio

SUBMITTER: Kedzia K 

PROVIDER: S-EPMC11632432 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature