Mutational differences between primary cancer tissue and circulating tumor cells in early-stage non-small cell lung cancer.

ABSTRACT:

Background

Early-stage non-small cell lung cancer (NSCLC) has a high recurrence rate despite proper management, including curative surgery. Circulating tumor cells (CTCs) are believed to play a key role in the distant metastasis of lung cancer. Immunofluorescence imaging studies of CTCs have revealed that they are associated with the prognosis of NSCLC. However, the mutational profiling of CTCs from early-stage NSCLC has not been extensively explored. We hypothesized that CTCs could be detected by mutational analysis using panel sequencing and would have distinct mutations associated with distant metastasis compared to those of primary cancer tissue in early-stage NSCLC. Thus, this study examined the DNA from CTCs using targeted panel sequencing to identify mutations and compared t

SUBMITTER: Kim W 

PROVIDER: S-EPMC11632435 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature