Engineering Granular Hydrogels without Interparticle Cross-Linking to Support Multicellular Organization.

ABSTRACT: Advancing three-dimensional (3D) tissue constructs is central to creating in vitro models and engineered tissues that recapitulate biology. Materials that are permissive to cellular behaviors, including proliferation, morphogenesis of multicellular structures, and motility, will support the emergence of tissue structures. Granular hydrogels in which there is no interparticle cross-linking exhibit dynamic properties that may be permissive to such cellular behaviors. However, designing granular hydrogels that lack interparticle cross-linking but support cellular self-organization remains underexplored relative to granular systems stabilized by interparticle cross-linking. In this study, we developed a polyethylene glycol-based granular hydrogel system, with average particle diameters

SUBMITTER: Claxton NL 

PROVIDER: S-EPMC11632665 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature