Intravenous thrombolysis in young adults with ischemic stroke: A cohort study from the international TRISP collaboration.

ABSTRACT:

Background and aims

Previous observational data indicate that young adults treated with intravenous thrombolysis (IVT) for acute ischemic stroke have more favorable outcomes and less complications when compared to older adults. Given the limited data on this topic, we aimed to provide more evidence on clinical outcomes and safety in such patients, using a large international thrombolysis registry.

Methods

In this prospective multicenter study, we used data from the Thrombolysis in Ischemic Stroke Patients (TRISP) registry from 1998 to 2020. Patients who received endovascular treatment (EVT), as only treatment or in addition to IVT, were not included in this cohort. Using multivariable regression models, we compared thrombolysed young patients aged 18-49 years with those aged

SUBMITTER: Nybondas M 

PROVIDER: S-EPMC11632716 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature