Added prognostic value of DCE blood volume imaging in patients with suspected recurrent or residual glioblastoma-A hybrid [¹⁸F]FET PET/MRI study.

ABSTRACT:

Background

Magnetic resonance imaging (MRI) cerebral blood volume (CBV) measurements improve the diagnosis of recurrent gliomas. The study investigated the prognostic value of dynamic contrast-enhanced (DCE) CBV imaging in treated IDH wildtype glioblastoma when added to MRI or amino acid positron emission tomography (PET).

Methods

Hybrid [¹⁸F]FET PET/MRI with 2CXM (2-compartment exchange model) DCE from 86 adult patients with suspected recurrent or residual glioblastoma were retrospectively analyzed. High CBV tumor volume (VOL_CBV), and contrast-enhancing (VOL_CE) and [¹⁸F]FET active tumor (VOL_FET) volumes were delineated. Absolute and fractional high CBV subvolumes within VOL_CE and VOL_FET were determ

SUBMITTER: Henriksen OM 

PROVIDER: S-EPMC11632823 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature