Impact of Overweight on Renal Prognosis in Malignant Hypertension Patients With Thrombotic Microangiopathy.

ABSTRACT:

Objective

Overweight and obesity is a risk factor for hypertension. Malignant hypertension (MHT) is the most severe form of hypertension, and thrombotic microangiopathy (TMA), one of its complications, has been linked to significant renal outcomes. However, the impact of overweight and obesity on renal prognosis in MHT patients with TMA is not well understood.

Methods

This was a prospective cohort enrolled 288 MHT patients with renal TMA from 2008 to 2023. The clinical and histopathological characteristics were recorded based on body mass index (BMI, < 25 and ≥ 25 kg/m²). The outcome was the incidence of kidney failure. The associations of BMI with kidney failure were examined in logistic regression models.

Results

Among 288 patients, 180 (62.5%) progressed

SUBMITTER: He F 

PROVIDER: S-EPMC11632844 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature