Prognostic model based on centrosome-related genes constructed in head and neck squamous cell carcinoma.

ABSTRACT: Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumor in the epithelium of the head and neck. The role of the centrosome in malignant tumors is crucial. However, research on the centrosome in HNSCC remains largely unexplored. In this study, bioinformatics tools were utilized to analyze the expression and prognostic significance of centrosome-related genes (CRGs). CRGs exhibited a relatively high mutation frequency in HNSCC. Consensus unsupervised clustering analysis based on the expression profiles of CRGs revealed significant associations with clinical features, prognosis and immune microenvironment in HNSCC. Prognostic features were constructed using univariate and LASSO Cox regression, resulting in a centrosome-related model with eleven features. Patients were

SUBMITTER: Zhang P 

PROVIDER: S-EPMC11632974 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature