Causal relationships between immune cells, plasma metabolites and lung adenocarcinoma: a two-step, two-sample Mendelian randomization study.

ABSTRACT: Background: Immune cells are crucial components of the immune system and significantly influence tumor progression. However, their direct involvement in lung adenocarcinoma (LUAD) and the potential mediation by plasma metabolites remain unclear. We performed a two-step, two-sample Mendelian randomization (MR) study to explore these connections between immune cells, plasma metabolites, and LUAD. Methods: We collected data from the GWAS database and performed an MR study employing the inverse variance weighting (IVW) method. We calculated the total effect of immune cells on LUAD, the effect of immune cells on plasma metabolites, and the effect of plasma metabolites on LUAD. Additionally, we calculated the mediating effect and mediated proportion to explore the causal role of im

SUBMITTER: Zhou W 

PROVIDER: S-EPMC11632987 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature