Genetic Variants at PRKCG Splice and UTR Sites Promote Cancer Susceptibility by Disrupting Epigenetic and miRNA Regulatory Network.

ABSTRACT: The changes in the protein kinase C gamma gene (PRKCG) expression are associated with both coding and non-coding variants. No studies have specifically established the association between PRKCG 3'UTR, 5'UTR, donor and acceptor splice variants with post-transcriptional changes through utilizing in-silico tools. The current study intends to uncover this linkage. In total, 419 3' and 5'UTR variants were retrieved. 325 of these variant IDs were annotated as functionally significant. 18 variants impacted the transcription factors binding and therefore influenced the post-transcriptional regulatory activity while 7 variants affected regulatory mechanisms through histone modifications. 2 rsIDs (rs373228, rs446795) potentially impacted the interactions with RNA binding proteins. In addition

SUBMITTER: Abid F 

PROVIDER: S-EPMC11632988 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature