Perirhinal cortex to the nucleus accumbens circuit in novelty salience following methamphetamine self-administration.

ABSTRACT: Methamphetamine (meth) use disorder is part of an overarching use disorder that encompasses continued drug seeking and an increased risk of returning to drug use following periods of abstaining. Chronic meth use results in drug-induced cortical plasticity in the perirhinal cortex (PRC) that mediates responses to novelty. PRH projection targets are numerous and include the nucleus accumbens core (NAc). Whereas the PRH-prefrontal cortex is involved in object recognition; we propose that the PRH-NAc is involved in novelty salience. Rats underwent short-access (ShA, 1 hr) or long-access (LgA, 6 hr) meth self-administration (SA). We then used a dual viral strategy to inhibit or activate PRH-NAc during a novel cue test in which rats were presented with meth-associated and novel levers. Response

SUBMITTER: Nelson KH 

PROVIDER: S-EPMC11633022 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature